Ensuring sterile, contamination-free environments through specialised interior construction techniques.
Why Hygiene-Focused Construction Matters
Clean rooms and pharmaceutical manufacturing areas demand stringent cleanliness, surface control, and airtight environmental engineering. The interior construction must prevent microbial growth, particle accumulation, and chemical interaction, while complying with Good Manufacturing Practices (GMP), ISO 14644, and FDA standards.
Design Principles for Hygienic Interiors
- Seamless Surfaces: Wall and ceiling junctions should be coved and smooth to prevent dust buildup and microbial growth.
- Airlock Zones: Multi-chamber layouts with gradient pressure control reduce airborne contamination risk.
- Flush Installations: Lighting, switches, and HVAC grills must be flush-mounted to prevent recesses and surface interruptions.
- Positive Pressure Design: Clean rooms are kept under positive pressure to prevent entry of unfiltered air.
Interior Materials for Clean Room Construction
Materials must be non-porous, non-shedding, corrosion-resistant, and easy to clean:
- Wall Panels: High-pressure laminate (HPL), PVC-coated steel, or powder-coated aluminium.
- Ceilings: Aluminium honeycomb or epoxy-coated gypsum tiles.
- Flooring: Seamless epoxy, PU, or vinyl flooring with anti-static and anti-fungal properties.
- Doors: Hermetically sealed doors with interlocking systems for pressure integrity.
- Sealants: Medical-grade silicone and polyurethane with antibacterial formulations.
Mechanical & Environmental Systems Integration
Interior construction must coordinate with HVAC, filtration, and lighting systems. Critical features include:
- HEPA/ULPA Filters: Must be ceiling-integrated and easy to replace.
- Laminar Airflow Systems: Ensure vertical airflow to sweep particles away from critical zones.
- Clean Room Lighting: Dust-tight, low-heat, and flicker-free, typically LED panels sealed behind tempered glass.
- Antimicrobial Coatings: Applied to high-touch interior surfaces for long-term protection.
Regulatory Compliance in India
Interior construction for pharmaceutical clean rooms must comply with multiple standards including:
- GMP Guidelines by WHO and India’s Schedule M
- ISO 14644 classification for air cleanliness levels
- CDSCO Standards for Indian pharmaceutical environments
- US FDA & EU GMP if exporting pharmaceuticals globally
Documented validation of surfaces, finishes, and environmental controls is often required before operation.
Case Study: Clean Room Fit-Out in Kerala Pharma Plant
In a recent pharmaceutical build in Thrissur, a Class 100,000 cleanroom interior was constructed using:
- Antistatic epoxy flooring
- PVC wall panels with radius corners
- Flush-mounted LED panels and HEPA modules
- Integrated interlock doors and pass boxes
The project passed full GMP validation and became operational within 8 weeks of handover.
Our Expertise in Hygienic Interior Construction
Constructions Kerala provides turnkey interior construction for sterile, clinical, and lab spaces. We work across:
- Pharma & Biotech Production Zones
- Diagnostic & IVF Labs
- Food-Grade Packing Areas
- Electronics Assembly Units
We prioritise contaminant-resistant materials, fast-track modular builds, and compliant designs backed by certified engineers. Get in touch for clean room consultation and execution in Kerala and South India.